A Technology
Platform for
Measuring Hidden
Physical Biology

In Physico combines nanoscale electrostatic sensing, dynamic phenotyping, AI-supported analysis, and predictive disease modeling.

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A Technology Platform for Measuring Hidden Physical Biology

SUPPORTED BY COLLABORATIONS ACROSS ACADEMIA AND MEDICINE

PLATFORM

Connecting Measurement,
Learning, and Prediction

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In Physico connects physical measurement, AI-driven learning, and predictive modeling into a single discovery framework.

It turns physical signals from living systems into interpretable signatures for disease and therapy response modeling.

Physical Measurement Layer Icon

Physical Measurement Layer

Capture electrostatic and biophysical signals from living biological systems.

AI Science Layer Icon

AI Science Layer

Identify hidden patterns, knowledge gaps, and biological signatures.

Predictive Modeling Layer Icon

Predictive Modeling Layer

Transform physical signatures into disease and therapeutic response models.

TECHNOLOGY PLATFORM

Core Platform Components

Four integrated components work together to transform physical measurements into predictive biological insight.

ChargeViewer graphic

ChargeViewer™

Capture hidden physical signals from living biological systems.

Dynamic Phenotyping™

Track biological changes continuously across time and conditions.

Dynamic Phenotyping graphic

AI Science Engine™

Reveal hidden patterns through AI-powered scientific analysis.

AI Science Engine graphic
Digital Disease Models graphic

Digital Disease Models™

Build predictive models from physical biological measurements.

DYNAMIC PHENOTYPING

Local Nanoscopic Charge
Dynamics Over Time

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Sequential model updating under uncertaintyAn animated scientific figure showing a Bayesian model updating its prediction curve as new measurements are added, with uncertainty bands narrowing over time.Sequential model updating under uncertaintyResponse (normalized)Experimental condition1.00.80.60.40.20.002468101214Knowledge gapPrior uncertaintyPredictionconfidencePrior uncertaintyInitial estimateObserved measurementNew measurementPosterior modelUpdated modelposterior fitNew measurementreduces uncertaintyinphysico.comBayesian sequential learning · n=10
ABOUT CHARGEVIEWER™

From Physical Measurement
to Predictive Insight

In Physico connects living biological systems, physical measurements, AI-supported interpretation, and predictive modeling into one continuous technology flow.

Sample Icon

1. Sample

Living cells, tissues, organoids, or biological interfaces are studied under biologically relevant conditions.

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2. Sensing

ChargeViewer uses ultrasensitive probes to image surface charge distributions without deforming samples.

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3. AI Analysis

AI-supported analysis identifies meaningful electrostatic patterns and relationships across biological systems.

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4. Physical Signature

Measured signals are translated into interpretable physical signatures linked to biological states and responses.

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5. Prediction

Physical signatures support predictive modeling of biological behavior, therapeutic response, and disease progression.

DISCOVERY ENGINE

From Knowledge Gaps
to Advanced Predictive
Models.

The Discovery Engine extends In Physico technology into a closed-loop system for identifying gaps.

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CONTINUOUS
SCIENTIFIC
LEARNING
1. Knowledge Gaps1. Knowledge Gaps
2. Hypothesis Generation2. Hypothesis Generation
3. Experiment Design3. Experiment Design
4. ChargeViewer Measurements4. ChargeViewer Measurements
5. Dynamic Phenotyping5. Dynamic Phenotyping
6. Digital Disease Models6. Digital Disease Models

Challenge

Identify unresolved biological questions.

Input

Existing research, data, and literature.

Output

Prioritized knowledge gaps for investigation.

PARTNERS

Scientific Collaborations
That Move Discovery Forward

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Dartmouth-Hitchcock Logo
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Oregon State University Logo
University of Maryland Baltimore Washington Medical Center Logo
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Florida International University Logo
Institute for Stem Cell and Regenerative Medicine Logo

Bring Physical Biology
Into Your Research

Discover how physical measurement, AI-supported analysis,
and predictive modeling can support biomedical research.

Physical Biology Cell Representation Graphic