ChargeViewer™

Reveal Hidden Electrostatic
Landscapes in Living Systems

ChargeViewer reveals invisible electrostatic patterns in living systems — turning physical insights into breakthroughs in biology and medicine.

Explore Technology
01

Sample

Biological systems in their native environment

02

Sensing

Nanoscale electrostatic imaging

03

AI Analysis

AI-powered pattern and signature analysis

04

Interpretation

Biological insight and mechanistic understanding

05

Prediction

Predict outcomes and guide better decisions

SUPPORTED BY COLLABORATIONS ACROSS ACADEMIA AND MEDICINE

CHARGEVIEWER™

What is ChargeViewer™?

Learn How It Works

ChargeViewer is a physical biology platform that measures electrostatic and biophysical signatures in living systems.

By revealing patterns invisible to conventional methods, it helps researchers understand dynamic biological states and responses.

Biological Signal Icon

Earlier Biological Signals

Detect physical changes before conventional endpoints reveal them.

Response Tracking Icon

Dynamic Response Tracking

Observe how living systems respond across time, conditions, and experimental interventions.

Translational Understanding Icon

Better Translational Understanding

Connect physical measurements to disease mechanisms and therapeutic response.

Biological backdrop
WHAT CHARGEVIEWER MEASURES

From Living Systems
to Physical Signatures

ChargeViewer captures electrostatic and biophysical signals from living biological systems and translates them into measurable physical signatures that can reveal hidden states, responses, and disease-relevant changes.

Cells Icon

Cells

Living cells under investigation

Tissues Icon

Tissues

Biological structures in relevant conditions

Organoids Icon

Organoids

Complex model systems for disease research

Biological Interfaces Icon

Biological Interfaces

Nano–bio and cell–environment interactions

ChargeViewer™

Nanoscale electrostatic sensing + AI-supported interpretation.

Physical Signatures

ElectrostaticBiophysicalDynamic

Measurable signals associated with biological state, therapeutic response, and disease progression.

HOW IT WORKS

How ChargeViewer Works

ChargeViewer combines biologically relevant samples,
nanoscale electrostatic sensing, AI-supported analysis, and scientific interpretation to transform physical measurements into actionable biological insight.

Sample Icon

1. Sample

Living cells, tissues, organoids, or biological interfaces are studied under biologically relevant conditions.

Sensing Icon

2. Sensing

ChargeViewer applies ultrasensitive probes capable of imaging surface charge distributions without deforming a sample.

AI Analysis Icon

3. AI Analysis

AI models identify meaningful electrostatic patterns, biological relationships, and emerging signal changes.

Physical Signature Icon

4. Physical Signature

Transform raw measurements into interpretable physical signatures linked to biological states and dynamic responses.

Prediction Icon

5. Prediction

Use identified signatures to predict biological responses and support better research and experimental decisions.

WHAT IT REVEALS

Revealing Biological States Conventional Methods Often Miss

ChargeViewer helps researchers detect hidden physical signals that influence disease progression, therapeutic response, and dynamic biological behavior.

Surface Charge Organization Timeline Icon

Surface Charge Organization

Detect how electrostatic patterns are distributed across living cell and tissue surfaces.

Surface Charge Organization Graphic
Bio-Interface Interactions Timeline Icon

Bio-Interface Interactions

Understand how cells, tissues, nanoparticles, and biological environments physically interact.

Bio-Interface Interactions Graphic
Glycocalyx Remodeling Timeline Icon

Glycocalyx Remodeling

Observe changes in the protective outer layer of cells that can influence disease behavior and response.

Glycocalyx Remodeling Graphic
Dynamic Tissue Responses Timeline Icon

Dynamic Tissue Responses

Track how living tissues physically respond over time to disease, treatment, or environmental change.

Dynamic Tissue Responses Graphic

A New Charge Map of Living Biology

ChargeViewer™ maps local electrostatic inhomogeneity across living biological surfaces — revealing nanoscale patterns that change over time.

Fig. 3 — Dynamic electrostatic charge map of a living cell surface (ChargeViewer™)INPHYSICO™ · LOCAL INHOMOGENEITY MODE−4−20246810420−2−4−6−8x-position (μm)y-position (μm)TRACKED NANOSCOPIC DOMAINTIME-DEPENDENT LOCAL FLUCTUATIONTracked nanoscopic region · sequential charge mapsT₁t = 0 sT₂t = 2.4 sT₃t = 4.8 sCharge island nucleates, migrates, and dissipates+electrostatic potentialLocal Δφ over 4.8 s windown = 3 sequential mapsΔt = 2.4 sTime-dependent fluctuation of electrostatic domain+1.0+0.50.0−0.5−1.0Relative electrostatic potential (a.u.)φ (a.u.)· sampled at 14 points· 250 × 250 nm² pixels· Δt = 2.4 s / frame· 37 °C, PBS bufferLocal charge inhomogeneityElectrostatic domain shiftDynamic local signal← scan origin2 μminphysico.comChargeViewer™ · electrostatic topography of living cell surfaces · dynamic charge domain tracking
PARTNERS

Scientific Collaborations
That Move Discovery Forward

Explore all Partners
Massachusetts Institute of Technology Logo
Harvard Medical School Logo
Dartmouth-Hitchcock Logo
Northwestern University Logo
University of Washington Logo
Oregon State University Logo
University of Maryland Baltimore Washington Medical Center Logo
University of Maryland Logo
Florida International University Logo
Institute for Stem Cell and Regenerative Medicine Logo

Bring Physical Biology
Into Your Research

Explore how ChargeViewer can support biological research,
therapeutic response studies, and predictive discovery.

Physical Biology Cell Representation Graphic