The Science
Behind
ChargeViewer™

Explore the science behind In Physico — from nanoscale measurements to validated biological insights.

Explore our Partners
The Science Behind ChargeViewer

SUPPORTED BY COLLABORATIONS ACROSS ACADEMIA AND MEDICINE

SCIENCE

Built on Measurement,
Validation, and Evidence

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The science behind ChargeViewer™ begins with measurable physical biology and extends through validation, interpretation, and supporting evidence.

Here, we outline the methods, research foundation, and technical principles that shape the platform's scientific framework.

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Measurement Methods

Nanoscale approaches for capturing electrostatic and biophysical signals in living systems.

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Research Evidence

Peer-reviewed publications and scientific work supporting the platform's foundation.

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Technical Context

Explanations of the principles, workflows, and questions behind the technology.

SCIENTIFIC FOUNDATION

Measuring the Physical
Layer of Biology

Living Systems

Study biological samples under conditions that preserve their native physical state for accurate measurement.

Living SystemsNanoscale SensingPhysical SignaturesBiological Insight
DYNAMIC PHENOTYPING

Dynamic Charge Landscape of a Living Surface

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CHARGEVIEWERKPFM · Nanoscale Surface Potential MappingLocal charge heterogeneity resolved at sub-10 nm spatial resolutionCELL SURFACE · CHARGE MAP200 nmKPFM electrostatic map · living cell surface · ChargeViewer™Selected RegionMEASUREMENT GRID · 20×20 ptsKPFM SURFACE POTENTIAL · 80×80 continuous field050100150200X (nm)050100150200Y (nm)P1+68 mVP2+74 mVL1−47 mVP3+81 mV50 nm+89 mV+44 mV0−44 mV−89 mVSurface potential (mV)Δf–DISTANCE SPECTROSCOPYTip–sample distance (nm)Δf (Hz)P2 (+)L1 (−)Spatial Resolution ≤ 8 nmΔV: −89 to +89 mV · tip r ≈ 25 nm · lift: 15 nm · KPFM AM mode
EVIDENCE

Built for Scientific Confidence

In Physico's approach is grounded in measurable signals, longitudinal analysis, reproducible workflows, and scientific validation.

High-Resolution Measurements

High-Resolution Measurements.

Longitudinal Analysis

Tracking biological changes across time and conditions.

Reproducibility

Structured workflows for consistent experimental validation.

Publications

Scientific work supporting the physical biology approach.

Performance

Sensitivity and benchmark comparisons for nanoscale heterogeneity.

PARTNERS

Scientific Collaborations
That Move Discovery Forward

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Institute for Stem Cell and Regenerative Medicine Logo

Bring Physical Biology
Into Your Research

Learn how ChargeViewer’s physical biology approach
can support research, validation, and predictive discovery.

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