DISCOVERY ENGINE

Turning Biological
Measurements into
Continuously Improving
Scientific Knowledge

The Discovery Engine connects physical measurements, AI-supported hypothesis generation, experiment design.

Explore scientific foundation
Discovery Engine Network Visual
Sequential model updating under uncertaintyAn animated scientific figure showing a Bayesian model updating its prediction curve as new measurements are added, with uncertainty bands narrowing over time.Sequential model updating under uncertaintyResponse (normalized)Experimental condition1.00.80.60.40.20.002468101214Knowledge gapPrior uncertaintyPredictionconfidencePrior uncertaintyInitial estimateObserved measurementNew measurementPosterior modelUpdated modelposterior fitNew measurementreduces uncertaintyINPHYSICO.COMBAYESIAN SEQUENTIAL LEARNING · N=10

SUPPORTED BY COLLABORATIONS ACROSS ACADEMIA AND MEDICINE

DISCOVERY SYSTEM

A Closed-Loop System for
Scientific Discovery

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The Discovery Engine helps transform biological data into a continuously improving research process.

It identifies knowledge gaps, generates hypotheses, guides experiment design, captures new measurements, and updates predictive disease models.

Knowledge Gaps Icon

Knowledge Gaps

Identify where current biological understanding may be incomplete.

AI Hypotheses Icon

AI Hypotheses

Generate testable research directions from complex biological and physical data.

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Model Updates

Use new measurements to improve predictive representations of disease behavior.

DISCOVERY LOOP

From Knowledge Gaps
to Updated Models

Each cycle of the Discovery Engine turns questions into experiments, experiments into measurements, and measurements into updated scientific understanding.

CONTINUOUS
SCIENTIFIC
LEARNING
1. Knowledge Gaps1. Knowledge Gaps
2. Hypothesis Generation2. Hypothesis Generation
3. Experiment Design3. Experiment Design
4. ChargeViewer Measurements4. ChargeViewer Measurements
5. Dynamic Phenotyping5. Dynamic Phenotyping
6. Digital Disease Models6. Digital Disease Models

01 Knowledge Gaps

Identify unanswered biological or therapeutic questions that require deeper investigation.

RESEARCH CONTEXT

Powered by AI Integration with the help of our Software Development Partner

CodePhusion

AI That Helps Guide Better Experiments

The AI Science Engine supports discovery by identifying patterns, knowledge gaps, generating hypotheses, and helping prioritize next-step experiments.

01

Pattern Recognition

Detect relationships across physical, biological, and temporal data.

02

Knowledge Gap Detection

Highlight areas where existing understanding may be incomplete.

03

Hypothesis Generation

Suggest testable research directions from measured signals.

04

Experiment Prioritization

Help select experiments likely to generate useful insight.

Sequential model updating under uncertaintyAn animated scientific figure showing a Bayesian model updating its prediction curve as new measurements are added, with uncertainty bands narrowing over time.Sequential model updating under uncertaintyResponse (normalized)Experimental condition1.00.80.60.40.20.002468101214Knowledge gapPrior uncertaintyPredictionconfidencePrior uncertaintyInitial estimateObserved measurementNew measurementPosterior modelUpdated modelposterior fitNew measurementreduces uncertaintyinphysico.comBayesian sequential learning · n=10
PARTNERS

Scientific Collaborations
That Move Discovery Forward

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Dartmouth-Hitchcock Logo
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Oregon State University Logo
University of Maryland Baltimore Washington Medical Center Logo
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Institute for Stem Cell and Regenerative Medicine Logo

Bring Physical Biology
Into Your Research

Discover how physical measurement, AI-supported analysis,
and predictive modeling can support biomedical research.

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